Hyponatremia Promotes Cancer Growth in a Murine Xenograft Model of Neuroblastoma.

ABSTRACT: In cancer patients, hyponatremia is detected in about 40% of cases at hospital admission and has been associated to a worse outcome. We have previously observed that cancer cells from different tissues show a significantly increased proliferation rate and invasion potential, when cultured in low extracellular [Na⁺]. We have recently developed an animal model of hyponatremia using Foxn1nu/nu mice. The aim of the present study was to compare tumor growth and invasivity of the neuroblastoma cell line SK-N-AS in hyponatremic vs. normonatremic mice. Animals were subcutaneously implanted with luciferase-expressing SK-N-AS cells. When masses reached about 100 mm³, hyponatremia was induced in a subgroup of animals via desmopressin infusion. Tumor masses were significantly gre

SUBMITTER: Marroncini G 

PROVIDER: S-EPMC10706371 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature