Medication-Related Osteonecrosis of the Jaw: A Systematic Review and a Bioinformatic Analysis.

ABSTRACT: The objective was to evaluate the current evidence regarding the etiology of medication-related osteonecrosis of the jaw (MRONJ). This study systematically reviewed the literature by searching PubMed, Web of Science, and ProQuest databases for genes, proteins, and microRNAs associated with MRONJ from the earliest records through April 2023. Conference abstracts, letters, review articles, non-human studies, and non-English publications were excluded. Twelve studies meeting the inclusion criteria involving exposure of human oral mucosa, blood, serum, saliva, or adjacent bone or periodontium to anti-resorptive or anti-angiogenic agents were analyzed. The Cochrane Collaboration risk assessment tool was used to assess the quality of the studies. A total of 824 differentially expressed genes/pro

SUBMITTER: Laputkova G 

PROVIDER: S-EPMC10706386 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature