Wireframe DNA Origami for the Cellular Delivery of Platinum(II)-Based Drugs.

ABSTRACT: The DNA origami method has revolutionized the field of DNA nanotechnology since its introduction. These nanostructures, with their customizable shape and size, addressability, nontoxicity, and capacity to carry bioactive molecules, are promising vehicles for therapeutic delivery. Different approaches have been developed for manipulating and folding DNA origami, resulting in compact lattice-based and wireframe designs. Platinum-based complexes, such as cisplatin and phenanthriplatin, have gained attention for their potential in cancer and antiviral treatments. Phenanthriplatin, in particular, has shown significant antitumor properties by binding to DNA at a single site and inhibiting transcription. The present work aims to study wireframe DNA origami nanostructures as possible carriers for

SUBMITTER: De Luca E 

PROVIDER: S-EPMC10706596 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature