Large-Scale Analysis of Meniscus Morphology as Risk Factor for Knee Osteoarthritis.

ABSTRACT:

Objective

Although it is established that structural damage of the meniscus is linked to knee osteoarthritis (OA) progression, the predisposition to future development of OA because of geometric meniscal shapes is plausible and unexplored. This study aims to identify common variations in meniscal shape and determine their relationships to tissue morphology, OA onset, and longitudinal changes in cartilage thickness.

Methods

A total of 4,790 participants from the Osteoarthritis Initiative data set were studied. A statistical shape model was developed for the meniscus, and shape scores were evaluated between a control group and an OA incidence group. Shape features were then associated with cartilage thickness changes over 8 years to localize the relationship between meniscus s

SUBMITTER: Gao KT 

PROVIDER: S-EPMC10706605 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature