<i>Aerococcus viridans</i> Phage Lysin AVPL Had Lytic Activity against <i>Streptococcus suis</i> in a Mouse Bacteremia Model.

ABSTRACT: Streptococcus suis (S. suis) is a swine pathogen that can cause sepsis, meningitis, endocarditis, and other infectious diseases; it is also a zoonotic pathogen that has caused a global surge in fatal human infections. The widespread prevalence of multidrug-resistant S. suis strains and the decline in novel antibiotic candidates have necessitated the development of alternative antimicrobial agents. In this study, AVPL, the Aerococcus viridans (A. viridans) phage lysin, was found to exhibit efficient bactericidal activity and broad lytic activity against multiple serotypes of S. suis. A final concentration of 300 μg/mL AVPL reduced S. suis counts by 4-4.5 log10 within 1 h in vitro. Importantly, AVPL effectively inhibited 48 h S. suis bi

SUBMITTER: Xi H 

PROVIDER: S-EPMC10706753 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature