Associations between Host Genetic Variants and Subgingival Microbiota in Patients with the Metabolic Syndrome.

ABSTRACT: Host genetic variants may affect oral biofilms, playing a role in the periodontitis-systemic disease axis. This is the first study to assess the associations between host genetic variants and subgingival microbiota in patients with metabolic syndrome (MetS); 103 patients with MetS underwent medical and periodontal examinations and had blood and subgingival plaque samples taken. DNA was extracted and processed, assessing a panel of selected single nucleotide polymorphisms (SNPs) first (hypothesis testing) and then expanding to a discovery phase. The subgingival plaque microbiome from these patients was profiled. Analysis of associations between host genetic and microbial factors was performed and stratified for periodontal diagnosis. Specific SNPs within RUNX2, CAMTA1 and VDR

SUBMITTER: Nibali L 

PROVIDER: S-EPMC10706808 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature