Changes of Ex Vivo Cervical Epithelial Cells Due to Electroporation with JMY.

ABSTRACT: The ionic environment within the nucleoplasm might diverge from the conditions found in the cytoplasm, potentially playing a role in the cellular stress response. As a result, it is conceivable that interactions of nuclear actin and actin-binding proteins (ABPs) with apoptosis factors may differ in the nucleoplasm and cytoplasm. The primary intracellular stress response is Ca²⁺ influx. The junctional mediating and regulating Y protein (JMY) is an actin-binding protein and has the capability to interact with the apoptosis factor p53 in a Ca²⁺-dependent manner, forming complexes that play a regulatory role in cytoskeletal remodelling and motility. JMY's presence is observed in both the cytoplasm and nucleoplasm. Here, we show that ex vivo ectocervical squamous cells sub

SUBMITTER: Halasz H 

PROVIDER: S-EPMC10706833 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature