Ontology highlight
ABSTRACT:
SUBMITTER: Zeyn Y
PROVIDER: S-EPMC10706967 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Zeyn Yanira Y Hobernik Dominika D Wilk Ulrich U Pöhmerer Jana J Hieber Christoph C Medina-Montano Carolina C Röhrig Nadine N Strähle Caroline F CF Thoma-Kress Andrea K AK Wagner Ernst E Bros Matthias M Berger Simone S
International journal of molecular sciences 20231129 23
Deeper knowledge about the role of the tumor microenvironment (TME) in cancer development and progression has resulted in new strategies such as gene-based cancer immunotherapy. Whereas some approaches focus on the expression of tumoricidal genes within the TME, DNA-based vaccines are intended to be expressed in antigen-presenting cells (e.g., dendritic cells, DCs) in secondary lymphoid organs, which in turn induce anti-tumor T cell responses. Besides effective delivery systems and the requireme ...[more]