MiR-195-5p as Regulator of γ-Catenin and Desmosome Junctions in Colorectal Cancer.

ABSTRACT: Desmosomes play a key role in the regulation of cell adhesion and signaling. Dysregulation of the desmosome complex is associated with the loss of epithelial cell polarity and disorganized tissue architecture typical of colorectal cancer (CRC). The aim of this study was to investigate and characterize the effect of miR-195-5p on desmosomal junction regulation in CRC. In detail, we proposed to investigate the deregulation of miR-195-5p and JUP, a gene target that encodes a desmosome component in CRC patients. JUP closely interacts with desmosomal cadherins, and downstream, it regulates several intracellular transduction factors. We restored the miR-195-5p levels by transient transfection in colonic epithelial cells to examine the effects of miR-195-5p on JUP mRNA and protein expressi

SUBMITTER: Piccinno E 

PROVIDER: S-EPMC10707010 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature