HDAC1: An Essential and Conserved Member of the Diverse Zn²⁺-Dependent HDAC Family Driven by Divergent Selection Pressure.

ABSTRACT: Zn²⁺-dependent histone deacetylases (HDACs) are enzymes that regulate gene expression by removing acetyl groups from histone proteins. These enzymes are essential in all living systems, playing key roles in cancer treatment and as potential pesticide targets. Previous phylogenetic analyses of HDAC in certain species have been published. However, their classification and evolutionary origins across biological kingdoms remain unclear, which limits our understanding of them. In this study, we collected the HDAC sequences from 1451 organisms and performed analyses. The HDACs are found to diverge into three classes and seven subclasses under divergent selection pressure. Most subclasses show species specificity, indicating that HDACs have evolved with high plasticity and diversificat

SUBMITTER: Yang JF 

PROVIDER: S-EPMC10707265 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature