Lipopolysaccharide Impedes Bone Repair in FcγRIIB-Deficient Mice.

ABSTRACT: Chronic inflammation contributes to the development of skeletal disorders in patients with systemic lupus erythematosus (SLE). Activation of the host immune response stimulates osteoclast activity, which in turn leads to bone loss. Regenerating bone in the inflammatory microenvironments of SLE patients with critical bone defects remains a great challenge. In this study, we utilized lipopolysaccharide (LPS) to imitate locally and systemically pathogenic bacterial infection and examined the bone regeneration performance of LPS-associated mandibular and tibial bone regeneration impairment in FcγRIIB^-/- mice. Our results indicated that a loss of FcγRIIB alleviates bone regeneration in both mandibles and tibiae. After LPS induction, FcγRIIB^-/- mice wer

SUBMITTER: Jantaboon S 

PROVIDER: S-EPMC10707393 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature