Exploring the Potential of Plant Bioactive Compounds against Male Infertility: An In Silico and In Vivo Study.

ABSTRACT: Infertility is a well-recognized multifactorial problem affecting the majority of people who struggle with infertility issues. In recent times, among infertility cases, the male factor has acquired importance, and now it contributes to approximately half of the infertility cases because of different abnormalities. In the current study, we used natural phytochemicals as potential drug-lead compounds to target different receptor proteins that are involved in the onset of male infertility. A set of 210 plant phytochemicals were docked counter to active site residues of sex hormone-binding globulin, a disintegrin and metalloproteinase 17, and DNase I as receptor proteins. On the basis of binding scores and molecular dynamics simulation, the phytochemicals tricin, quercetin, malvidin, rhamnetin

SUBMITTER: Jahangeer M 

PROVIDER: S-EPMC10707554 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature