Inferring multi-locus selection in admixed populations.

ABSTRACT: Admixture, the exchange of genetic information between distinct source populations, is thought to be a major source of adaptive genetic variation. Unlike mutation events, which periodically generate single alleles, admixture can introduce many selected alleles simultaneously. As such, the effects of linkage between selected alleles may be especially pronounced in admixed populations. However, existing tools for identifying selected mutations within admixed populations only account for selection at a single site, overlooking phenomena such as linkage among proximal selected alleles. Here, we develop and extensively validate a method for identifying and quantifying the individual effects of multiple linked selected sites on a chromosome in admixed populations. Our approach numerically calcul

SUBMITTER: Ayala NM 

PROVIDER: S-EPMC10707604 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature