Intracellular Fate of Sub-Toxic Concentration of Functionalized Selenium Nanoparticles in Aggressive Prostate Cancer Cells.

ABSTRACT: Selenium 0 (Se⁰) is a powerful anti-proliferative agent in cancer research. We investigated the impact of sub-toxic concentrations of Se⁰ functionalized nanoparticles (SeNPs) on prostate cancer PC-3 cells and determined their intracellular localization and fate. An in-depth characterization of functionalized selenium nanoparticles composition is proposed to certify that no chemical bias relative to synthesis issues might have impacted the study. Selenium is an extremely diluted element in the biological environment and therefore requires high-performance techniques with a very low detection limit and high spatial resolution for intracellular imaging. This was explored with state-of-the-art techniques, but also with cryopreparation to preserve the chemical and structur

SUBMITTER: Bissardon C 

PROVIDER: S-EPMC10707848 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature