In Vitro Anti-Inflammatory Activity of Methyl Derivatives of Flavanone.

ABSTRACT: Inflammation plays an important role in the immune defense against injury and infection agents. However, the inflammatory chronic process may lead to neurodegenerative diseases, atherosclerosis, inflammatory bowel diseases, or cancer. Flavanones present in citrus fruits exhibit biological activities, including anti-oxidative and anti-inflammatory properties. The beneficial effects of flavanones have been found based on in vitro cell cultures and animal studies. A suitable in vitro model for studying the inflammatory process are macrophages (RAW264.7 cell line) because, after stimulation using lipopolysaccharide (LPS), they release inflammatory cytokines involved in the immune response. We determined the nitrite concentration in the macrophage cell culture and detected ROS using chemilumine

SUBMITTER: Klosek M 

PROVIDER: S-EPMC10708004 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature