Anti-Trypanosoma cruzi Potential of Vestitol Isolated from Lyophilized Red Propolis.

ABSTRACT: Chagas disease (CD) is a worldwide public health problem, and the drugs available for its treatment have severe limitations. Red propolis is a natural extract known for its high content of phenolic compounds and for having activity against T. cruzi. The aim of this study was to investigate the trypanocidal potential of red propolis to isolate, identify, and indicate the mode of action of the bioactive compounds. The results revealed that the total phenolic content was 15.4 mg GAE/g, and flavonoids were 7.2 mg QE/g. The extract was fractionated through liquid-liquid partitioning, and the trypanocidal potential of the samples was evaluated using the epimastigote forms of the Y strain of T. cruzi. In this process, one compound was characterized by MS, ¹H, and ^13<

SUBMITTER: Sousa LRD 

PROVIDER: S-EPMC10708512 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature