Treatment and outcome of the Dutch Childhood Craniopharyngioma Cohort study: First results after centralization of care.

ABSTRACT:

Background

Childhood craniopharyngioma (cCP) has excellent survival, but quality of life may be severely hampered by hypothalamic dysfunction. We aimed to evaluate treatment and hypothalamic outcomes of a Dutch cCP cohort, and evaluate the effect of centralization of care.

Methods

A retrospective cohort study was performed, including cCP patients diagnosed between 2004 and 2021. Treatment characteristics and hypothalamic outcomes were evaluated and compared before and since centralization of care in May 2018.

Results

We included 87 cCP patients. Cyst drainage/fenestration was performed in 29.9%, limited resection in 27.6%, near-total resection in 16.1%, and gross total resection (GTR) in 25.4%. Radiotherapy was given in 46.0%. After a median follow-up of 6.5 years, hy

SUBMITTER: Van Schaik J 

PROVIDER: S-EPMC10708930 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature