A novel risk signature for predicting brain metastasis in patients with lung adenocarcinoma.

ABSTRACT:

Background

Brain metastasis (BM) are a devastating consequence of lung cancer. This study was aimed to screen risk factors for predicting BM.

Methods

Using an in vivo BM preclinical model, we established a series of lung adenocarcinoma (LUAD) cell subpopulations with different metastatic ability. Quantitative proteomics analysis was used to screen and identify the differential protein expressing map among subpopulation cells. Q-PCR and Western-blot were used to validate the differential proteins in vitro. The candidate proteins were measured in LUAD tissue samples (n = 81) and validated in an independent TMA cohort (n = 64). A nomogram establishment was undertaken by performing multivariate logistic regression analysis.

Results

The quantitative proteomics analysis, qP

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC10708939 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature