The relationship between late (≥ 7 days) systemic dexamethasone and functional network connectivity in very preterm infants.

ABSTRACT:

Background

Current evidence shows that systemic dexamethasone administration starting after the first week of age reduces bronchopulmonary dysplasia for very preterm (VPT) infants, but its neurological effects remain obscure. Using resting-state functional magnetic resonance imaging (rs-fMRI), we assessed the changes in functional network connectivity (FNC) in very preterm infants treated with late systemic dexamethasone (≥7 days of age).

Methods

VPT infants (GA ≤ 32 weeks) who needed to rely on mechanical ventilation for more than 7 days but fewer than 14 days to maintain vital signs were included in the study. The cohort was divided into two groups according to whether they were given systemic dexamethasone. In addition, 26 healthy term infants were recruited as con

SUBMITTER: Jia W 

PROVIDER: S-EPMC10709020 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature