Testing the triple network model of psychopathology in a transdiagnostic neurodevelopmental cohort.

ABSTRACT:

Aim

The triple network model of psychopathology posits that altered connectivity between the Salience (SN), Central Executive (CEN), and Default Mode Networks (DMN) may underlie neurodevelopmental conditions. However, this has yet to be tested in a transdiagnostic sample of young people.

Method

We investigated this in 175 children (60 girls) that represent a heterogeneous population who are experiencing neurodevelopmental difficulties in cognition and behavior, and 60 comparison children (33 girls). Hyperactivity/impulsivity and inattention were assessed by parent-report. Resting-state functional Magnetic Resonance Imaging data were acquired and functional connectivity was calculated between independent network components and regions of interest. We then examined whether con

SUBMITTER: Jones JS 

PROVIDER: S-EPMC10709083 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature