Dataset Information

Anaerobic pathogens associated with OSA may contribute to pathophysiology via amino-acid depletion.

ABSTRACT:

Background

The human microbiome is linked to multiple metabolic disorders such as obesity and diabetes. Obstructive sleep apnoea (OSA) is a common sleep disorder with several metabolic risk factors. We investigated the associations between the gut microbiome composition and function, and measures of OSA severity in participants from a prospective community-based cohort study: the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Methods

Bacterial-Wide Association Analysis (BWAS) of gut microbiome measured via metagenomics with OSA measures was performed adjusting for clinical, lifestyle and co-morbidities. This was followed by functional analysis of the OSA-enriched bacteria. We utilized additional metabolomic and transcriptomic associations to suggest possible mechanisms explaining the microbiome effects on OSA.

Findings

Several uncommon anaerobic human pathogens were associated with OSA severity. These belong to the Lachnospira, Actinomyces, Kingella and Eubacterium genera. Functional analysis revealed enrichment in 49 processes including many anaerobic-related ones. Severe OSA was associated with the depletion of the amino acids glycine and glutamine in the blood, yet neither diet nor gene expression revealed any changes in the production or consumption of these amino acids.

Interpretation

We show anaerobic bacterial communities to be a novel component of OSA pathophysiology. These are established in the oxygen-poor environments characteristic of OSA. We hypothesize that these bacteria deplete certain amino acids required for normal human homeostasis and muscle tone, contributing to OSA phenotypes. Future work should test this hypothesis as well as consider diagnostics via anaerobic bacteria detection and possible interventions via antibiotics and amino-acid supplementation.

Funding

Described in methods.

SUBMITTER: Elgart M

PROVIDER: S-EPMC10709109 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Publications

Anaerobic pathogens associated with OSA may contribute to pathophysiology via amino-acid depletion.

Elgart Michael M Zhang Ying Y Zhang Yuan Y Yu Bing B Kim Youngmee Y Zee Phyllis C PC Gellman Marc D MD Boerwinkle Eric E Daviglus Martha L ML Cai Jianwen J Redline Susan S Burk Robert D RD Kaplan Robert R Sofer Tamar T

EBioMedicine 20231124

<h4>Background</h4>The human microbiome is linked to multiple metabolic disorders such as obesity and diabetes. Obstructive sleep apnoea (OSA) is a common sleep disorder with several metabolic risk factors. We investigated the associations between the gut microbiome composition and function, and measures of OSA severity in participants from a prospective community-based cohort study: the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).<h4>Methods</h4>Bacterial-Wide Association Analys ...[more]

PMID: 38006744

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Dataset Information

Anaerobic pathogens associated with OSA may contribute to pathophysiology via amino-acid depletion.

Background

Methods

Findings

Interpretation

Funding

Publications

Anaerobic pathogens associated with OSA may contribute to pathophysiology via amino-acid depletion.

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