Anaerobic pathogens associated with OSA may contribute to pathophysiology via amino-acid depletion.

ABSTRACT:

Background

The human microbiome is linked to multiple metabolic disorders such as obesity and diabetes. Obstructive sleep apnoea (OSA) is a common sleep disorder with several metabolic risk factors. We investigated the associations between the gut microbiome composition and function, and measures of OSA severity in participants from a prospective community-based cohort study: the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Methods

Bacterial-Wide Association Analysis (BWAS) of gut microbiome measured via metagenomics with OSA measures was performed adjusting for clinical, lifestyle and co-morbidities. This was followed by functional analysis of the OSA-enriched bacteria. We utilized additional metabolomic and transcriptomic associations to suggest possible me

SUBMITTER: Elgart M 

PROVIDER: S-EPMC10709109 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature