A multi-organ maize metabolic model connects temperature stress with energy production and reducing power generation.

ABSTRACT: Climate change has adversely affected maize productivity. Thereby, a holistic understanding of metabolic crosstalk among its organs is important to address this issue. Thus, we reconstructed the first multi-organ maize metabolic model, iZMA6517, and contextualized it with heat and cold stress transcriptomics data using expression distributed reaction flux measurement (EXTREAM) algorithm. Furthermore, implementing metabolic bottleneck analysis on contextualized models revealed differences between these stresses. While both stresses had reducing power bottlenecks, heat stress had additional energy generation bottlenecks. We also performed thermodynamic driving force analysis, revealing thermodynamics-reducing power-energy generation axis dictating the nature of temperature stress resp

SUBMITTER: Chowdhury NB 

PROVIDER: S-EPMC10709110 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature