Direct entry of micro(nano)plastics into human blood circulatory system by intravenous infusion.

ABSTRACT: Understanding the pathways of human exposure to micro(nano)plastics (MNPs) is crucial for assessing their health impacts. Intravenous infusion can induce MNPs direct entry into the human blood, posing serious risks on human health, but remains unclear. Herein, we developed comprehensive analytical methods to detect polyvinyl chloride (PVC) MNPs down to 20 nm, and found about 0.52 μg equal to 10⁵-10¹¹ particles of PVC-MNPs released from intravenous infusion products (IVIPs) during each intravenous infusion of 250 mL injection. The released amounts of MNPs from IVIPs were dependent on the plastic materials, and the injection volume and composition. These findings indicated that the released MNPs should be directly introduced into the human blood circulatory system, caus

SUBMITTER: Li P 

PROVIDER: S-EPMC10709129 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature