Probe-based confocal laser endomicroscopy for evaluating high-altitude pulmonary edema in canines.

ABSTRACT:

Background

Real-time assessment of high-altitude pulmonary edema (HAPE) remains a challenge. Probe-based confocal laser microscopy (pCLE) allows a real-time in vivo visualization of the alveoli. This study aimed to develop a new non-invasive method for analyzing microscopic images in a canine model of HAPE using pCLE.

Materials and methods

This was a prospective, controlled animal study in adult male beagle dogs randomized to control and HAPE groups. The HAPE group was exposed to a high altitude of 6000 m for 48 h. The blood gas levels, lung morphological changes, infectious factors, and lung wet-to-dry ratio were analyzed in different groups. The pCLE images were described based on the volume air index (VAI), which applies an integral over specific signal intensities.

Re

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10709167 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature