Diabetes Mellitus and Poor Glycemic Control Negatively Impact Clinical Outcomes and Survival in Patients with Compensated Cirrhosis.

ABSTRACT:

Background and objectives

Diabetes mellitus (DM) increases morbidity and mortality in advanced cirrhosis. Information on the prognostic impact of DM in compensated cirrhosis is scarce. We aimed to explore the effect of DM and glycemic control on the natural history of compensated cirrhotic patients.

Methods

This retrospective longitudinal cohort study included Child A/B cirrhosis without or free from decompensation or hospitalization > 1 year. Data on survival, unplanned hospitalization, hepatic decompensation (ascites, portal hypertension-related bleeding, hepatic encephalopathy, acute kidney injury), new infection, and hepatocellular carcinoma (HCC) were collected.

Results

457 patients were included (71.3% Child A, model for end-stage liver disease [MELD] 9.9 ± 3.1,

SUBMITTER: Boonpiraks K 

PROVIDER: S-EPMC10709187 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature