Unveiling the mechanisms of nephrotoxicity caused by nephrotoxic compounds using toxicological network analysis.

ABSTRACT: Billions of people worldwide have experienced irreversible kidney injuries, which is mainly attributed to the complexity of drug-induced nephrotoxicity. Consequently, there is an urgent need for uncovering the mechanisms of nephrotoxicity caused by compounds. In the present study, a network-based methodology was applied to explore the mechanisms of nephrotoxicity induced by specific compounds. Initially, a total of 42 nephrotoxic compounds and 60 kinds of syndromes associated with nephrotoxicity were collected from public resources. Afterward, network localization and separation algorithms were used to map the targets of compounds and diseases into the human interactome. By doing so, 199 statistically significant nephrotoxic networks displaying the interaction between compound targets and

SUBMITTER: Xi K 

PROVIDER: S-EPMC10709196 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature