Multicenter phase II trial of transanal total mesorectal excision for rectal cancer: preliminary results.

ABSTRACT:

Background

Transanal TME (taTME) combines abdominal and transanal dissection to facilitate sphincter preservation in patients with low rectal tumors. Few phase II/III trials report long-term oncologic and functional results. We report early results from a North American prospective multicenter phase II trial of taTME (NCT03144765).

Methods

100 patients with stage I-III rectal adenocarcinoma located ≤ 10 cm from the anal verge (AV) were enrolled across 11 centers. Primary and secondary endpoints were TME quality, pathologic outcomes, 30-day and 90-day outcomes, and stoma closure rate. Univariable regression analysis was performed to assess risk factors for incomplete TME and anastomotic complications.

Results

Between September 2017 and April 2022, 70 males and 30 femal

SUBMITTER: Sylla P 

PROVIDER: S-EPMC10709232 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature