ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis.

ABSTRACT:

Aims/hypothesis

The brain is a major consumer of glucose as an energy source and regulates systemic glucose as well as energy balance. Although glucose transporters such as GLUT2 and sodium-glucose cotransporter 2 (SGLT2) are known to regulate glucose homeostasis and metabolism, the identity of a receptor that binds glucose to activate glucose signalling pathways in the brain is unknown. In this study, we aimed to discover a glucose receptor in the mouse hypothalamus.

Methods

Here we used a high molecular mass glucose-biotin polymer to enrich glucose-bound mouse hypothalamic neurons through cell-based affinity chromatography. We then subjected the enriched neurons to proteomic analyses and identified adhesion G-protein coupled receptor 1 (ADGRL1) as a top candidate for a glu

SUBMITTER: Chhabra KH 

PROVIDER: S-EPMC10709246 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature