Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes.

ABSTRACT:

Aims/hypothesis

Compromised pancreatic sympathetic innervation has been suggested as a factor involved in both immune-mediated beta cell destruction and endocrine dysregulation of pancreatic islets. To further explore these intriguing findings, new techniques for in vivo assessment of pancreatic innervation are required. This is a retrospective study that aimed to investigate whether the noradrenaline (norepinephrine) analogue ¹¹C-hydroxy ephedrine (¹¹C-HED) could be used for quantitative positron emission tomography (PET) imaging of the sympathetic innervation of the human pancreas.

Methods

In 25 individuals with type 2 diabetes and 64 individuals without diabetes, all of whom had previously undergone ¹¹C-HED-PET/CT because of pheochromocyto

SUBMITTER: Vyakaranam AR 

PROVIDER: S-EPMC10709256 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature