Unknown

Dataset Information

0

Additional predictive value of optic nerve sheath diameter for neurological prognosis after cardiac arrest: a prospective cohort study.


ABSTRACT:

Background

The goal is to estimate the additional value of ultrasonographic optic nerve sheath diameter (ONSD) measurement on days 1-3, on top of electroencephalography (EEG), pupillary light reflexes (PLR), and somatosensory evoked potentials (SSEP), for neurological outcome prediction of comatose cardiac arrest patients. We performed a prospective longitudinal cohort study in adult comatose patients after cardiac arrest. ONSD was measured on days 1-3 using ultrasound. Continuous EEG, PLR, and SSEP were acquired as standard care. Poor outcome was defined as cerebral performance categories 3-5 at 3-6 months. Logistic regression models were created for outcome prediction based on the established predictors with and without ONSD. Additional predictive value was assessed by increase in sensitivity for poor (at 100% specificity) and good outcome (at 90% specificity).

Results

We included 100 patients, 54 with poor outcome. Mean ONSD did not differ significantly between patients with good and poor outcome. Sensitivity for predicting poor outcome increased by adding ONSD to EEG and SSEP from 25% to 41% in all patients and from 27% to 50% after exclusion of patients with non-neurological death.

Conclusions

ONSD on days 1-3 after cardiac arrest holds potential to add to neurological outcome prediction.

Trial registration

clinicaltrials.gov, NCT04084054. Registered 10 September 2019, https://www.

Clinicaltrials

gov/study/NCT04084054 .

SUBMITTER: Verhulst MMLH 

PROVIDER: S-EPMC10709263 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Additional predictive value of optic nerve sheath diameter for neurological prognosis after cardiac arrest: a prospective cohort study.

Verhulst Marlous M L H MMLH   Visser Iris M IM   Keijzer Hanneke M HM   de Kruijf Nicole L M NLM   Peters Erwin J G EJG   Wilbers Thom T   Peelen Roel V RV   Hofmeijer Jeannette J   Blans Michiel J MJ  

The ultrasound journal 20231208 1


<h4>Background</h4>The goal is to estimate the additional value of ultrasonographic optic nerve sheath diameter (ONSD) measurement on days 1-3, on top of electroencephalography (EEG), pupillary light reflexes (PLR), and somatosensory evoked potentials (SSEP), for neurological outcome prediction of comatose cardiac arrest patients. We performed a prospective longitudinal cohort study in adult comatose patients after cardiac arrest. ONSD was measured on days 1-3 using ultrasound. Continuous EEG, P  ...[more]

Similar Datasets

| S-EPMC8296417 | biostudies-literature
| S-EPMC9207325 | biostudies-literature
| S-EPMC6999916 | biostudies-literature
| S-EPMC8613366 | biostudies-literature
| S-EPMC9668157 | biostudies-literature
| S-EPMC8027451 | biostudies-literature
| S-EPMC9537149 | biostudies-literature
| S-EPMC5017836 | biostudies-literature
| S-EPMC8953152 | biostudies-literature
| S-EPMC8138150 | biostudies-literature