Circulating miRNA profiles in COVID-19 patients and meta-analysis: implications for disease progression and prognosis.

ABSTRACT: We compared circulating miRNA profiles of hospitalized COVID-positive patients (n = 104), 27 with acute respiratory distress syndrome (ARDS) and age- and sex-matched healthy controls (n = 18) to identify miRNA signatures associated with COVID and COVID-induced ARDS. Meta-analysis incorporating data from published studies and our data was performed to identify a set of differentially expressed miRNAs in (1) COVID-positive patients versus healthy controls as well as (2) severe (ARDS+) COVID vs moderate COVID. Gene ontology enrichment analysis of the genes these miRNAs interact with identified terms associated with immune response, such as interferon and interleukin signaling, as well as viral genome activities associated with COVID disease and severity. Additionally, we observed downregulati

SUBMITTER: Gao L 

PROVIDER: S-EPMC10709343 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature