Secreted miR-210-3p, miR-183-5p and miR-96-5p reduce sensitivity to docetaxel in prostate cancer cells.

ABSTRACT: Docetaxel (DCT) resistance is one of the main factors responsible for treatment failure in metastatic prostate cancer (PCa). Although several mechanisms of DCT resistance have been elucidated, the issue is still far from comprehensive. In this work we show that miR-96-5p, miR-183-5p and miR-210-3p (referred to as sDCT^R-miRNAs) are specifically released by DCT resistant (DCT^R) PCa clones and decrease the efficacy of DCT in PCa cells when overexpressed. Through bioinformatic analysis, we identified several potential targets of sDCT^R-miRNAs' activity including FOXO1, IGFBP3, and PDCD4 known to exert a role in DCT resistance. Additionally, we found that PPP2CB and INSIG1 mediated the ability of sDCT^R-miRNAs to reduce the efficacy of DCT. We explored

SUBMITTER: Canovai M 

PROVIDER: S-EPMC10709610 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature