Norepinephrine regulates calcium signals and fate of oligodendrocyte precursor cells in the mouse cerebral cortex.

ABSTRACT: Oligodendrocyte precursor cells (OPCs) generate oligodendrocytes, contributing to myelination and myelin repair. OPCs contact axons and respond to neuronal activity, but how the information relayed by the neuronal activity translates into OPC Ca²⁺ signals, which in turn influence their fate, remains unknown. We generated transgenic mice for concomitant monitoring of OPCs Ca²⁺ signals and cell fate using 2-photon microscopy in the somatosensory cortex of awake-behaving mice. Ca²⁺ signals in OPCs mainly occur within processes and confine to Ca²⁺ microdomains. A subpopulation of OPCs enhances Ca²⁺ transients while mice engaged in exploratory locomotion. We found that OPCs responsive to locomotion preferentially differentiate into oligoden

SUBMITTER: Fiore F 

PROVIDER: S-EPMC10709653 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature