Early skeletal muscle loss in adolescent and young adult cancer patients treated with anthracycline chemotherapy.

ABSTRACT:

Background

Early skeletal muscle loss has been observed in adolescent and young adult (AYA) sarcoma patients undergoing treatment. Identification of individuals within the AYA populace that are at greatest risk of anthracycline-induced skeletal muscle loss is unknown. Moreover, investigations which seek out underlying causes of skeletal muscle degradation during chemotherapy are critical for understanding, preventing, and reducing chronic health conditions associated with poor skeletal muscle status.

Methods

Computed tomography (CT) scans were used to investigate changes in skeletal muscle of 153 AYA sarcoma and Hodgkin lymphoma patients at thoracic vertebra 4 after anthracycline treatment. Images were examined at three time points during the first year of treatment. In para

SUBMITTER: Wooten SV 

PROVIDER: S-EPMC10709738 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature