Minocycline and Diacetyl Minocycline Eye Drops Reduce Ocular Neovascularization in Mice.

ABSTRACT:

Purpose

To evaluate the efficacy of minocycline and a novel, modified minocycline analogue that lacks antimicrobial action, diacetyl minocycline (DAM), on choroidal neovascularization (CNV) in mice of both sexes.

Methods

CNV was induced via laser injury in female and male C57BL/6J mice. Minocycline, DAM, or saline was administered via topical eye drops twice a day for 2 weeks starting the day after laser injury. CNV volume was measured using immunohistochemistry labeling and confocal microscopy.

Results

Minocycline reduced lesion volume by 79% (P ≤ 0.0004) in female and male mice. DAM reduced lesion volume by 73% (P ≤ 0.001) in female and male mice. There was no significant difference in lesion volume between minocycline and DAM treatment groups or between female and

SUBMITTER: Willms JO 

PROVIDER: S-EPMC10709801 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature