Allele-specific binding (ASB) analyzer for annotation of allele-specific binding SNPs.

ABSTRACT:

Background

Allele-specific binding (ASB) events occur when transcription factors (TFs) bind more favorably to one of the two parental alleles at heterozygous single nucleotide polymorphisms (SNPs). Evidence suggests that ASB events could reveal the impact of sequence variations on TF binding and may have implications for the risk of diseases.

Results

Here we present ASB-analyzer, a software platform that enables the users to quickly and efficiently input raw sequencing data to generate individual reports containing the cytogenetic map of ASB SNPs and their associated phenotypes. This interactive tool thereby combines ASB SNP identification, biological annotation, motif analysis, phenotype associations and report summary in one pipeline. With this pipeline, we identified 3772

SUBMITTER: Li Y 

PROVIDER: S-EPMC10709849 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature