Effects of diabetes mellitus and glycemic traits on cardiovascular morpho-functional phenotypes.

ABSTRACT:

Background

The effects of diabetes on the cardiac and aortic structure and function remain unclear. Detecting and intervening these variations early is crucial for the prevention and management of complications. Cardiovascular magnetic resonance imaging-derived traits are established endophenotypes and serve as precise, early-detection, noninvasive clinical risk biomarkers. We conducted a Mendelian randomization (MR) study to examine the association between two types of diabetes, four glycemic traits, and preclinical endophenotypes of cardiac and aortic structure and function.

Methods

Independent genetic variants significantly associated with type 1 diabetes, type 2 diabetes, fasting insulin (FIns), fasting glucose (FGlu), 2 h-glucose post-challenge (2hGlu), and glycated hem

SUBMITTER: Li Z 

PROVIDER: S-EPMC10709859 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature