Whole blood transcriptomics identifies subclasses of pediatric septic shock.

ABSTRACT:

Background

Sepsis is a highly heterogeneous syndrome, which has hindered the development of effective therapies. This has prompted investigators to develop a precision medicine approach aimed at identifying biologically homogenous subgroups of patients with septic shock and critical illnesses. Transcriptomic analysis can identify subclasses derived from differences in underlying pathophysiological processes that may provide the basis for new targeted therapies. The goal of this study was to elucidate pathophysiological pathways and identify pediatric septic shock subclasses based on whole blood RNA expression profiles.

Methods

The subjects were critically ill children with cardiopulmonary failure who were a part of a prospective randomized insulin titration trial to treat hy

SUBMITTER: Yang JO 

PROVIDER: S-EPMC10709863 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature