Causal associations between genetically determined common psychiatric disorders and the risk of falls: evidence from Mendelian randomization.

ABSTRACT:

Background

The causal associations between psychiatric disorders and falls risk remains uncertain. Consequently, this study aimed to explore the causal relationship between genetically determined three common psychiatric disorders and the risk of falls based on Mendelian randomization (MR).

Methods

The genome-wide association study (GWAS) data for schizophrenia (SCZ) (N = 320,404), major depressive disorder (MDD) (N = 480,359), and Alzheimer's disease (AD) (N = 63,926) were obtained as exposures. The GWAS data for falls risk (N = 451,179) was obtained as outcome. Univariate Mendelian randomization (UVMR) was used to evaluate the direct causal relationship between SCZ, MDD, AD, and risk of falls. Inverse variance weighting (IVW) was used as the primary analysis method. Sensit

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10709873 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature