Rapid intestinal and systemic metabolic reprogramming in an immunosuppressed environment.

ABSTRACT: Intrinsic metabolism shapes the immune environment associated with immune suppression and tolerance in settings such as organ transplantation and cancer. However, little is known about the metabolic activities in an immunosuppressive environment. In this study, we employed metagenomic, metabolomic, and immunological approaches to profile the early effects of the immunosuppressant drug tacrolimus, antibiotics, or both in gut lumen and circulation using a murine model. Tacrolimus induced rapid and profound alterations in metabolic activities within two days of treatment, prior to alterations in gut microbiota composition and structure. The metabolic profile and gut microbiome after seven days of treatment was distinct from that after two days of treatment, indicating continuous drug effects

SUBMITTER: Ma B 

PROVIDER: S-EPMC10709923 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature