Follicular fluid C3a-peptide promotes oocyte maturation through F-actin aggregation.

ABSTRACT:

Background

Immature cumulus-oocyte complexes are retrieved to obtain mature oocytes by in vitro maturation (IVM), a laboratory tool in reproductive medicine to obtain mature oocytes. Unfortunately, the efficiency of IVM is not satisfactory. To circumvent this problem, we therefore intended to commence with the composition of ovarian follicular fluid (FF), an important microenvironment influencing oocyte growth. It is well known that FF has a critical role in oocyte development and maturation. However, the components in human FF remain largely unknown, particularly with regard to small molecular peptides.

Results

In current study, the follicular fluid derived from human mature and immature follicles were harvested. The peptide profiles of FF were further investigated by using

SUBMITTER: Yang Y 

PROVIDER: S-EPMC10709936 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature