Pharmacokinetics of dexmedetomidine in anaesthetized horses following repeated subcutaneous administration and intravenous constant rate infusion.

ABSTRACT:

Background

The inclusion of dexmedetomidine (DEX) within a balanced general anaesthesia protocol is effective in improving the clinical outcome and recovery quality of anaesthesia in horses. This study aimed to determine the pharmacokinetic profile of DEX following repeated subcutaneous (SC) administration at 2 µg/kg every 60 min till the end of the procedure in comparison to intravenous constant rate infusion (CRI) at 1 µg/kg/h in anaesthetized horses undergoing diagnostic procedures up to the end of the diagnostic procedure.

Results

In the CRI and SC groups DEX maximum concentrations (C_max) were 0.83 ± 0.27 ng/mL and 1.14 ± 0.71 ng/mL, respectively, reached at a time (T_max) of 57.0 ± 13.4 min and 105.5 ± 29.9 min. Mean residence time to the last measu

SUBMITTER: Di Cesare F 

PROVIDER: S-EPMC10709979 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature