Heterogeneous Angular Spectrum Method for Trans-Skull Imaging and Focusing.

ABSTRACT: Ultrasound, alone or in concert with circulating microbubble contrast agents, has emerged as a promising modality for therapy and imaging of brain diseases. While this has become possible due to advancements in aberration correction methods, a range of applications, including adaptive focusing and tracking of the microbubble dynamics through the human skull, may benefit from even more computationally efficient methods to account for skull aberrations. Here, we derive a general method for the angular spectrum approach (ASA) in a heterogeneous medium, based on a numerical marching scheme to approximate the full implicit solution. We then demonstrate its functionality with simulations for (human) skull-related aberration correction and trans-skull passive acoustic mapping. Our simulations sho

SUBMITTER: Schoen S 

PROVIDER: S-EPMC10710012 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature