Study protocol for FIBROKIT: a new tool for fibromyalgia diagnosis and patient follow-up.

ABSTRACT: Fibromyalgia (FM) is a complex disease that is characterized by chronic musculoskeletal pain and has great economic impact. FM prevalence is about 2% to 4% worldwide, affecting mainly middle-aged women, and its complex pathophysiology complicates diagnosis, treatment and the findings of solid biomarkers. Previous studies have suggested an association between the disease and oxidative stress, mitochondrial metabolism, intestinal microbiota and inflammation, providing sufficient data to support the multifactorial origin of FM. Hence, the objective of this randomized, prospective, low-interventional, double-blinded and placebo-controlled clinical trial is the development of a specific panel of FM biomarkers and the evaluation of their response to a six-month nutritional intervention based on

SUBMITTER: Del Amo LL 

PROVIDER: S-EPMC10710143 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature