Genetically predicted serum testosterone and risk of gynecological disorders: a Mendelian randomization study.

ABSTRACT:

Background

Testosterone plays a key role in women, but the associations of serum testosterone level with gynecological disorders risk are inconclusive in observational studies.

Methods

We leveraged public genome-wide association studies to analyze the effects of four testosterone related exposure factors on nine gynecological diseases. Causal estimates were calculated by inverse variance-weighted (IVW), MR-Egger and weighted median methods. The heterogeneity test was performed on the obtained data through Cochrane's Q value, and the horizontal pleiotropy test was performed on the data through MR-Egger intercept and MR-PRESSO methods. "mRnd" online analysis tool was used to evaluate the statistical power of MR estimates.

Results

The results showed that total testostero

SUBMITTER: Zhao B 

PROVIDER: S-EPMC10710168 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature