Subcortical grey matter volume and asymmetry in the long-term course of Rasmussen's encephalitis.

ABSTRACT: Rasmussen's encephalitis is characterized by drug-resistant focal seizures and chronic inflammation of one hemisphere leading to progressive loss of hemispheric volume. In this cohort study, we aimed to investigate subcortical grey matter volumes and asymmetries in Rasmussen's encephalitis longitudinally in clinically relevant subgroups. We retrospectively included all T₁-weighted MRI scans of all people with Rasmussen's encephalitis who were treated at the University Hospital Bonn between 1995 and 2022 (n = 56, 345 scans, median onset 8 years, 36 female). All cases were classified as type 1 (onset ≤ 6 years) or type 2 (onset > 6 years). Subcortical segmentations were performed using FreeSurfer. Longitudinal trajectories of subcortical volumes and hemispheric ratios (ipsi

SUBMITTER: Bauer T 

PROVIDER: S-EPMC10710296 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature