Long-term effects of vaginal surgery and endogenous ovarian hormones on the vagina and bladder.

ABSTRACT:

Background

Surgery is a common treatment for pelvic organ prolapse (POP); however, risk of recurrence and reoperation is high, resulting in a negative impact on quality of life and sexual function.

Aim

To examine the long-term effects of POP surgery and endogenous circulating ovarian hormones on the vagina and bladder.

Methods

Our animal model simulated surgical injury of the vagina and bladder during POP surgery. Female Rowett nude rats were divided into 4 groups: intact control (IC), vaginal surgery only (V), ovariectomy only (O), and ovariectomy + vaginal surgery (OV). Rats were euthanized 10 weeks postsurgery. Proximal vagina and bladder dome/trigone underwent (1) organ bath myography to assess smooth muscle contractility; (2) real-time quantitative polymerase cha

SUBMITTER: Ho T 

PROVIDER: S-EPMC10710297 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature