Lifetime risk of severe kidney disease in lithium-treated patients: a retrospective study.

ABSTRACT:

Background

Lithium is an essential psychopharmaceutical, yet side effects and concerns about severe renal function impairment limit its usage.

Aims

Our objectives were to quantify the occurrence of chronic kidney disease stage 4 or higher (CKD4 +) within a lithium-treated population, using age- and time-specific cumulative incidence and age-specific lifetime risk as measures of disease occurrence. Additionally, we aimed to investigate the association between the duration of lithium treatment and the risk of CKD4 + .

Methods

We identified patients from the Sahlgrenska University Hospital's laboratory database. We conducted a retrospective cohort study employing cumulative incidence functions that account for competing deaths to estimate cumulative and lifetime risk of

SUBMITTER: Golic M 

PROVIDER: S-EPMC10710395 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature