Impact of IDO activation and alterations in the kynurenine pathway on hyperserotonemia, NAD⁺ production, and AhR activation in autism spectrum disorder.

ABSTRACT: Hyperserotonemia is the most replicated biochemical anomaly associated with autism spectrum disorder (ASD) and has been reported in 35-46% of individuals with ASD. Serotonin is synthesised from the essential amino acid tryptophan (TRP). However, the main catabolic route of TRP is the kynurenine pathway (KP), which competes with serotonin synthesis when indoleamine dioxygenase (IDO) is activated. Using the same cohort of individuals with ASD, we used to report extensive studies of the serotonin/melatonin pathway, and found increased kynurenine (KYN), suggesting IDO activation in 58.7% of individuals with ASD (159/271), supported by a strong negative correlation between KYN/TRP ratio and miR-153-3p plasma levels, which negatively regulates IDO. IDO activation was associated with normoseroton

SUBMITTER: Launay JM 

PROVIDER: S-EPMC10710433 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature