Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion.

ABSTRACT: Skull bone marrow is thought to be an immune tissue closely associated with the central nervous system (CNS). Recent studies have focused on the role of skull bone marrow in central nervous system disorders. In this study, we performed single-cell RNA sequencing on ipsilateral and contralateral skull bone marrow cells after experimental stroke and then performed flow cytometry and analysis of cytokine expression. Skull marrow showed lateralization in response to stroke. Lateralization is demonstrated primarily by the proliferation and differentiation of myeloid and lymphoid lineage cells in the skull bone marrow adjacent to the ischemic region, with an increased proportion of neutrophils compared to monocytes. Analysis of chemokines in the skull revealed marked differences in chemotactic s

SUBMITTER: Xu C 

PROVIDER: S-EPMC10710724 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature